TABLE 4.
Univariate and multivariate analysis of prognostic factors for OS and RFS in BC patients
| Factors | Univariate analysis (OS) | Multivariate analysis (OS) | Univariate analysis (RFS) | Multivariate analysis (RFS) | ||||
|---|---|---|---|---|---|---|---|---|
| HR (95% CI) | P‐value | HR (95% CI) | P‐value | HR (95% CI) | P‐value | HR (95% CI) | P‐value | |
| Age (≥65/<65) | 1.687 (0.59‐4.84) | .33 | – | – | 1.444 (0.51‐4.12) | .493 | – | – |
| Gender (male/female) | 2.341 (0.31‐17.80) | .411 | – | – | 2.622 (0.34‐20.12) | .354 | – | – |
| Tumor size (≥3 cm/< 3cm) | 1.262 (0.48‐3.33) | .639 | – | – | 1.341 (0.51‐3.55) | .555 | – | – |
| Mul. (multiple/single) | 1.545 (0.80‐2.99) | .196 | – | – | 1.189 (0.41‐3.42) | .749 | – | – |
| Lymph no. Met. (Yes/No) | 9.099 (2.59‐32.00) | .001 a | 3.427 (1.14‐10.33) | .029 a | 15.472 (3.44‐69.52) | <.001 a | 11.114 (1.19‐103) | .035 a |
| T stage (T2‐T4/Ta‐T1) | 7.666 (2.18‐26.93) | .001 a | 1.112 (0.32‐3.86) | .868 | 13.923 (2.97‐65.18) | .001 a | 1.702 (0.20‐14.7) | .628 |
| Grade (high/low) | 6.394 (1.77‐23.06) | .005 a | 1.634 (0.44‐6.13) | .467 | 9.48 (2.08‐43.27) | .004 a | 0.874 (0.10‐7.91) | .905 |
| Circ7837 (high/low) | 0.130 (0.03‐0.5) | .003 a | 0.352 (0.15‐0.82) | .016 a | 0.192 (0.06‐0.63) | .006 a | 0.232 (0.06‐0.97) | .045 a |
| Circ4826 (high/low) | 5.706 (1.81‐18.03) | .003 a | 0.352 (0.16‐0.77) | .008 a | 0.190 (0.06‐0.60) | .004 a | 0.252 (0.06‐1.07) | .062 |
Abbreviations: Circ4826, hsa_circ_0004826; Circ7837, hsa_circ_0077837; Lymph no. Met., Lymph node metastasis; Mul., Multiplicity; OS, Overall survival; RFS: Recurrence‐free survival.
a
Indicated statistical significance.