FIGURE 6.

Proposed mechanisms through which TP3 inhibited GBM infiltration and mobility. Upon the administration of TP3, the ECM of the TME balance is disturbed through modulating the expression levels of MMPs, MAPK, FAK, and AKT pathways. p38, ERK, and JNK, the mitogen‐activated protein kinases; ECM, extracellular matrix; FAK, focal adhesion kinase; GBM, glioblastoma multiforme; MAPK, mitogen‐activated protein kinase; MMPs, matrix metalloproteinases; TME, tumor microenvironment; TP3, tilapia piscidin 3