Table 1.
Clinical trials with hydroxychloroquine alone
| S. no. | Clinical trial study title | Intervention (drug/s) | Weblink to clinical trial |
|---|---|---|---|
| Hydroxychloroquine as prophylaxis drug against Covid-19 | |||
| 1 | Prophylaxis for Patients at Risk of COVID-19 infection | Drug: Hydroxychloroquine Sulfate 200 MG | https://ClinicalTrials.gov/show/NCT04389359 |
| 2 | Hydroxychloroquine Chemoprophylaxis in Healthcare Personnel in Contact With COVID-19 Patients (PHYDRA Trial) | Drug: Hydroxychloroquine|Drug: Placebo oral tablet | https://ClinicalTrials.gov/show/NCT04318015 |
| 3 | Randomized, Controlled, Double-blind Clinical Trial Comparing the Efficacy and Safety of Chemoprophylaxis With Hydroxychloroquine in Patients Under Biological Treatment and/or JAK Inhibitors in the Prevention of SARS-CoV-2 Infection | Drug: Hidroxicloroquina|Drug: Control group | https://ClinicalTrials.gov/show/NCT04330495 |
| 4 | PRophylaxis of Exposed COVID-19 Individuals With Mild Symptoms Using choloroquinE Compounds | Drug: Hydroxychloroquine Sulfate Regular dose|Drug: Hydroxychloroquine Sulfate Loading Dose|Drug: Chloroquine|Drug: Placebo | https://ClinicalTrials.gov/show/NCT04351191 |
| 5 | PROLIFIC ChemoprophylaxisTrial (COVID-19) | Drug: Hydroxychloroquine-Daily dosing|Drug: Hydroxychloroquine-Weekly Dosing|Other: Matched Placebo Hydroxychloroquine | https://clinicaltrials.gov/show/NCT04352933 |
| 6 | Immune Monitoring of Prophylactic Effect of Hydroxychloroquine in Healthcare Providers Highly Exposed to COVID-19 | Drug: Hydroxychloroquine|Drug: Placebo oral tablet | https://ClinicalTrials.gov/show/NCT04346329 |
| 7 | Pre-exposure Prophylaxis for SARS-Coronavirus-2 | Drug: Hydroxychloroquine|Other: Placebo | https://ClinicalTrials.gov/show/NCT04328467 |
| 8 | Post-Exposure Prophylaxis for Asymptomatic SARS-CoV-2 COVID-19 Patients With choloroquine Compounds | Drug: Hydroxychloroquine Sulfate Regular dose|Drug: Hydroxychloroquine Sulfate Loading Dose|Drug: Chloroquine|Drug: Placebo | https://ClinicalTrials.gov/show/NCT04346667 |
| 9 | Hydroxychloroquine as Prophylaxis for COVID-19 in Healthcare Workers (HCQPreP) | Drug: Hydroxychloroquine|Drug: Placebo | https://ClinicalTrials.gov/show/NCT04363450 |
| 10 | Assessment of the Efficacy and Safety of (HCQ) as a Prophylaxis for COVID19 for Health Professionals | Drug: Hydroxychloroquine (HCQ)|Drug: Placebo oral tablet | https://ClinicalTrials.gov/show/NCT04349228 |
| 11 | Protect: Study With Hydroxychloroquine for Prevention and Early Phase Treatment of Coronavirus Disease (COVID-19) | Drug: Hydroxychloroquine | https://ClinicalTrials.gov/show/NCT04363827 |
| 12 | HEalth Care Worker pROphylaxis Against COVID-19: The HERO Trial | Drug: Hydroxychloroquine Pre-Exposure Prophylaxis|Drug: Placebo oral tablet | https://ClinicalTrials.gov/show/NCT04352946 |
| 13 | Hydroxychloroquine as Chemoprevention for COVID-19 for High Risk Healthcare Workers | Drug: Hydroxychloroquine Sulfate (HCQ) | https://ClinicalTrials.gov/show/NCT04345653 |
| 14 | Hydroxychloroquine Post Exposure Prophylaxis for Coronavirus Disease (COVID-19) | Drug: Hydroxychloroquine|Drug: Placebo oral tablet | https://ClinicalTrials.gov/show/NCT04318444 |
| 15 | Pre-Exposure Prophylaxis With Hydroxychloroquine for High-Risk Healthcare Workers During the COVID-19 Pandemic | Drug: Hydroxychloroquine|Drug: Placebos | https://ClinicalTrials.gov/show/NCT04331834 |
| 16 | Prophylactic Benefit of Hydroxychloroquine in COVID-19 Cases With Mild to Moderate Symptoms and in Healthcare Workers With High Exposure Risk | Drug: Hydroxychloroquine Sulfate | https://ClinicalTrials.gov/show/NCT04371926 |
| 17 | Hydroxychloroquine Chemoprophylaxis for COVID-19 Infection in High-risk Healthcare Workers. | Drug: Hydroxychloroquine|Drug: Placebo oral tablet | https://ClinicalTrials.gov/show/NCT04370015 |
| 18 | Hydroxychloroquine as Post Exposure Prophylaxis for SARS-CoV-2(HOPE Trial) | Drug: Hydroxychloroquine as post exposure prophylaxis| | https://ClinicalTrials.gov/show/NCT04330144 |
| 19 | Does Hydroxychloroquine Before & During Patient Exposure Protect Healthcare Workers From Coronavirus? | Drug: Hydroxychloroquine|Drug: Placebo oral tablet | https://ClinicalTrials.gov/show/NCT04374942 |
| 20 | Hydroxychloroquine to Prevent COVID-19 Disease Amongst Healthcare Workers | Drug: Apo-Hydroxychloroquine|Drug: Matched Placebo | https://clinicaltrials.gov/show/NCT04371523 |
| 21 | Hydroxychloroquine Versus Placebo in COVID-19 Patients at Risk for Severe Disease | Drug: Hydroxychloroquine|Drug: Placebo | https://clinicaltrials.gov/show/NCT04325893 |
| Clinical trials on safety and efficacy of Hydroxychloroquine against Covid-19 | |||
| 22 | The PATCH Trial (Prevention And Treatment of COVID-19 With Hydroxychloroquine) | Drug: Hydroxychloroquine Sulfate 400 mg twice a day|Drug: Hydroxychloroquine Sulfate 600 mg twice a day|Drug: Hydroxychloroquine Sulfate 600 mg once a day|Drug: Placebo oral tablet | https://ClinicalTrials.gov/show/NCT04329923 |
| 23 | ALBERTA HOPE COVID-19 for the Prevention of Severe COVID19 Disease | Drug: Hydroxychloroquine | https://ClinicalTrials.gov/show/NCT04329611 |
| 24 | Hydroxychloroquine in SARS-CoV-2 (COVID-19) Pneumonia Trial | Drug: Hydroxychloroquine | https://clinicaltrials.gov/show/NCT04382625 |
| 25 | A Pilot Study to Assess Hydroxychloroquine in Patients With SARS-CoV-2 (COVID-19) | Drug: Hydroxychloroquine|Drug: Placebo | https://clinicaltrials.gov/show/NCT04363866 |
| 26 | COVID-19 PrEP HCW HCQ | StudyDrug: Hydroxychloroquine (HCQ) | https://ClinicalTrials.gov/show/NCT04354870 |
| 27 | Hydroxychloroquine in the Prevention of COVID-19 Infection in Healthcare Workers | Drug: Hydroxychloroquine | https://ClinicalTrials.gov/show/NCT04333225 |
| 28 | Norwegian Coronavirus Disease 2019 Study | Drug: Hydroxychloroquine Sulfate | https://ClinicalTrials.gov/show/NCT04316377 |
| 29 | Will Hydroxychloroquine Impede or Prevent COVID-19 | Drug: Hydroxychloroquine-Daily Dosing|Drug: Hydroxychloroquine-Weekly Dosing|Other: Placebo oral | https://ClinicalTrials.gov/show/NCT04341441 |
| 30 | A Study of Hydroxycholoroquine Compared to Placebo as Treatment for People With COVID-19 | Drug: Hydroxychloroquine|Other: Placebo | https://ClinicalTrials.gov/show/NCT04379492 |
| 31 | Efficacy and Safety of Hydroxychloroquine for Treatment of COVID-19 | Drug: Hydroxychloroquine | https://ClinicalTrials.gov/show/NCT04261517 |
| 32 | Chloroquine/Hydroxychloroquine Prevention of Coronavirus Disease (COVID-19) in the Healthcare Setting | Drug: Chloroquine or Hydroxychloroquine|Drug: Placebo | https://ClinicalTrials.gov/show/NCT04303507 |
| 33 | PATCH 2&3:Prevention & Treatment of COVID-19 (Severe Acute Respiratory Syndrome Coronavirus 2) With Hydroxychloroquine | Drug: Group A HCQ|Drug: Group B Control | https://ClinicalTrials.gov/show/NCT04353037 |
| 34 | Hydroxychloroquine Treatment of Healthcare Workers With COVID19 Illness at Montefiore | Drug: Hydroxychloroquine | https://ClinicalTrials.gov/show/NCT04350450 |
| 35 | Healthcare Worker Exposure Response and Outcomes of Hydroxychloroquine | Drug: Hydroxychloroquine|Drug: Placebo oral tablet | https://ClinicalTrials.gov/show/NCT04334148 |
| 36 | Safety And Efficacy Of Hydroxychloroquine For At Risk Population (SHARP) Against COVID-19 | Drug: Hydroxychloroquine Sulfate 200 mg (mg) Tab | https://ClinicalTrials.gov/show/NCT04342156 |
| 37 | University of Utah COVID-19 Hydrochloroquine Trial | Drug: Hydroxychloroquine|Drug: Placebo oral tablet | https://ClinicalTrials.gov/show/NCT04342169 |
| 38 | Outcomes Related to COVID-19 Treated With Hydroxychloroquine Among In-patients With Symptomatic Disease | Drug: Hydroxychloroquine|Drug: Placebo | https://ClinicalTrials.gov/show/NCT04332991 |
| 39 | Chloroquine Outpatient Treatment Evaluation for HIV-Covid-19 | Drug: Chloroquine or hydroxychloroquine | https://ClinicalTrials.gov/show/NCT04360759 |
| 40 | A Randomized Controlled Clinical Trial: Hydroxychloroquine for the Treatment of COVID-19 in Hospitalized Patients | Drug: Hydroxychloroquine | https://ClinicalTrials.gov/show/NCT04345692 |
| 41 | Trial of Hydroxychloroquine In Covid-19 | Drug: Hydroxychloroquine|Other: Placebo | https://ClinicalTrials.gov/show/NCT04353271 |
| 42 | Hydroxychloroquine for COVID-19 | Drug: Hydroxychloroquine Sulfate|Drug: Placebo | https://ClinicalTrials.gov/show/NCT04342221 |
| 43 | Efficacy and Tolerability of Hydroxychloroquine in Adult Patients With COVID-19 | Drug: Hydroxychloroquine Sulfate 200 MG [Plaquenil] | https://ClinicalTrials.gov/show/NCT04384380 |
| Clinical trials of Hydroxychloroquine as per severity of Covid-19 | |||
| 44 | Hydroxychloroquine for the Treatment of Mild COVID-19 Disease | Drug: Hydroxychloroquine|Drug: Placebo | https://ClinicalTrials.gov/show/NCT04340544 |
| 45 | Chloroquine, Hydroxychloroquine or Only Supportive Care in Patients AdmItted With Moderate to Severe COVID-19 | Drug: Chloroquine Sulfate|Drug: Hydroxychloroquine|Other: Standard supportive care | https://ClinicalTrials.gov/show/NCT04362332 |
| 46 | Hydroxychloroquine Treatment for Severe COVID-19 Pulmonary Infection (HYDRA Trial) | Drug: Hydroxychloroquine|Drug: Placebo oral tablet | https://ClinicalTrials.gov/show/NCT04315896 |
| 47 | Hydroxychloroquine for the Treatment of Patients With Mild to Moderate COVID-19 to Prevent Progression to Severe Infection or Death | Drug: Hydroxychloroquine|Other: The control group will not receive hydroxychloroquine | https://ClinicalTrials.gov/show/NCT04323631 |
| Clinical trials focusing on dose of Hydroxychloroquine against Covid-19 | |||
| 48 | High-dose Hydroxychloroquine for the Treatment of Ambulatory Patients With Mild COVID-19 | Drug: Hydroxychloroquine | https://ClinicalTrials.gov/show/NCT04351620 |
| 49 | Efficacy of Various Doses of Hydroxychloroquine in Pre-Exposure Prophylaxis for COVID 19 | Drug: Hydroxychloroquine Sulfate 200 MG|Other: Placebo | https://ClinicalTrials.gov/show/NCT04359537 |
| Clinical trials on effect of Hydroxychloroquine in COVID-19 Positive Pregnant Women | |||
| 50 | Effect of Hydroxychloroquine in COVID-19 Positive Pregnant Women | Drug: hydroxychloroquine sulfate 200 MG|Drug: Placebo oral tablet | https://ClinicalTrials.gov/show/NCT04354441 |
| Clinical trial for Hydroxychloroquine in Elderly positive Covid-19 people of age > 65 years | |||
| 51 | Test and Treat COVID 65plus + | Drug: Hydroxychloroquine|Other: Placebo | https://ClinicalTrials.gov/show/NCT04351516 |
HCQ Hydroxychloroquine