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. Author manuscript; available in PMC: 2020 Jun 10.
Published in final edited form as: Nat Rev Neurol. 2019 Jun 21;15(7):405–417. doi: 10.1038/s41582-019-0220-2

Figure 3. Heritable germline risk factors for the WHO 2016 subtypes of adult glioma.

Figure 3

Summary of the relationship between heritable germline risk factors and WHO 2016 classification. Overlapping boxes contain alterations shared by different diffuse glioma tumour subtypes. Involved genes are known to be relevant to the indicated biological pathways, but with a few exceptions the functional consequences of individual single-nucleotide polymorphisms (SNPs) are unknown. SNPs and gene names in bold were strongly associated with more than one WHO 2016 glioma subgroup in multivariant analyses. Data from REFS.19,126.