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Acvr2a cKO animals are hypogonadal. (A) Testicular weights and (B) testicular sperm counts in 8- to 10-week-old control and cKO-A males. (C) Average litter sizes from control and cKO-A females paired with wild-type males for 3 to 4 months. Ovarian (D) weights, (E) histology, (F) antral follicle counts, and (G) corpora lutea numbers in 9- to 10-week-old control and cKO-A females. Scale bar: 100 μm. t-tests were used for statistical analyses, *P < 0.05, **P < 0.01, ***P < 0.001.
