. Author manuscript; available in PMC: 2020 Jun 10.

Published in final edited form as: Int Forum Allergy Rhinol. 2018 Feb;8(2):108–352. doi: 10.1002/alr.22073

TABLE VIII.D-2.

Evidence for the role of validated survey instruments in the evaluation, diagnosis, and follow-up of allergic rhinitis

Study	Year	LOE	Study design	Study groups	Clinical endpoint	Conclusion
Di Bona et al.⁸¹⁵	2015	1a	Systematic review	ARC	Meta-analysis of grass SLIT efficacy	Combined symptom and medication score showed efficacy of grass SLIT.
Calderon et al.⁸⁰¹	2014	1a	Systematic review	AR	Comparison of scoring systems	TNSS and combined medication scores should be used in clinical trials.
Demoly et al.⁸⁰³	2016	1b	DBRPCT	AR	Efficacy of HDM SLIT tablet	TCRS confirmed efficacy of SLIT.
Zieglmayer et al.⁷⁹⁸	2016	1b	RCT	AR	Efficacy of B-cell vaccine	TNSS score used to determine efficacy in large study.
Klimek et al.⁸⁰⁵	2015	1b	RCT	ARC	Effectiveness of recombinant birch SCIT	Combined score and VAS revealed no difference between recombinant and standard birch SCIT.
Mosbech et al.⁷⁹⁹	2015	1b	RCT	AR	Efficacy of HDM SLIT for AR	RQLQ used effectively in this evaluation.
Devillier et al.⁸⁰²	2016	2b	Cohort	AR	Evaluation of AR by VAS, RTSS and RQLQ	Comparison of various outcome measures validates their utility.
Galimberti et al.⁸¹⁴	2015	2b	Cohort	AR, AC, asthma	Evaluation of RAP test	RAP test is valid for screening allergic disease
Devillier et al.⁸¹³	2014	2b	Cohort	ARC	Minimal clinically important difference of RTSS	RTSS vs RQLQ showed minimal clinically important difference of 1.
Hafner et al.⁸⁰⁶	2012	2b	Cohort	ARC	Evaluation of RC-ACS test in 81 subjects	RC-ACS is a valid test for evaluating ARC without asthma.

AC = allergic conjunctivitis; AR = allergic rhinitis; ARC = allergic rhinoconjunctivitis; DBRPCT = double-blind randomized placebo controlled trial; HDM = house dust mite; LOE = level of evidence; RAP = Respiratory Allergy Prediction; RC-ACS = Rhinoconjunctivitis Allergy Control Score; RCT = randomized controlled trial; RQLQ = Rhinoconjunctivitis Quality of Life Questionnaire; RTSS = Rhinoconjunctivitis Total Symptom Score; SCIT = subcutaneous immunotherapy; SLIT = sublingual immunotherapy; TCRS = Total Combined Rhinitis Score; TNSS = Total Nasal Symptom Score; VAS = visual analog scale.