TABLE VI.A.
Key findings from GWASs on allergic rhinitis or hay fever
| Author (year) |
Study design | Sample size | Ethnicity | Top SNPs for AR |
p | Nearby gene(s) |
Reported association with other allergic diseases |
Protein function | LOE |
|---|---|---|---|---|---|---|---|---|---|
| Bunyavanich et al.512 (2014) | Meta-analysis of 7 cohorts | 2712 AR cases; 2921 controls | EA, L, AA | rs17133587 | 4.5E–09 (L) | AKR1E2 | No | NAD(P)H-dependent oxidoreduction | 2a |
| rs6583203 | 1.4E–08 (L) | DLG1 | No | Scaffolding protein involved in cell metabolism | |||||
| rs7780001 | 2.0E–08 (all groups) | FERD3L | No | Transcription factor | |||||
| Hinds et al.487 (2013) | Private company data (23andMe) | 46,646 total | >97% EA | rs1438673 | 3.7E–19 | WDR36 | Asthma487, 513; eczema488; atopy487 | Cellular processes and T-cell activation | 2a |
| rs2101521 | 6.0E–17 | TLR1–TLR6; TLR10 | Asthma, eczema, atopy487 | Pathogen recognition and activation of innate immunity | |||||
| rs10189629 | 9.9E–15 | IL1RL2; IL1RL1 | Asthma487, 514; eczema487; atopy487 | Proinflammatory effects, T-helper cell function | |||||
| Andiappan et al.515 (2011) | Nested case-control with replication | 1132 AR cases; 997 controls | Chinese | rs811930 | 7.3E–05 | MRPL4 | No | Protein synthesis within the mitochondrion | 2a |
| rs505101 | 1.3E–04 | BCAP (PIK3AP1) | Atopy515 | Protein tyrosine kinase | |||||
| Ramasamy et al.488 (2011) | Meta-analysis of 4 cohorts | 3933 AR cases; 8965 controls | EA | rs2155219 | 3.8E–08 | LRRC32 or C11orf30, SLCA25A46 | Co-morbidity: asthma-atopy489; asthma-eczema491; asthma-hay fever486 Eczema,487, 490 asthma, atopy487 |
LRRC32: T-cell regulation, TGF-β activity. C11orf30: regulation of viral immunity and interferon pathways | 2a |
| rs17513503 | 7.4E–07 | TMEM232 | No | Transmembrane protein | |||||
| rs1044573 | 9.7E–07 | ENTPD6 | No | Catabolism of extracellular nucleotides | |||||
| Ferreira et al.486 (2010) | Meta-analysis of 4 cohorts/datasets | 16,513 hay fever cases; 17,256 controls | EA, L, AA | rs4833095 | 4E–12 | TLR1 | Asthma, eczema, atopy487 | Pathogen recognition and activation of innate immunity | 2a |
| rs2155219 | 7E–10 | LRRC32 or C11orf30 | Co-morbidity: asthma-atopy489; asthma-eczema491; asthma-hay fever486 Eczema,487, 490 asthma, atopy487 |
See above | |||||
| rs10197862 | 2E–09 | IL1RL1 | Asthma487, 514; eczema487; atopy487 | Proinflammatory effects, T-helper cell function |
AA = African American; AR = allergic rhinitis; EA = European ancestry; GWAS = genome-wide association study; L = Latino; LOE = level of evidence; NADPH = nicotinamide adenine dinucleotide phosphate.