Table 1.
Baseline demographics among BPD infants with and without PH
| Variable* | BPD-PH n=24 | No PH n=63 | P value |
|---|---|---|---|
| Gestational Age (weeks) | 24.7 (2.3) | 26.4 (3.7) | 0.02 |
| Birthweight (grams) | 765 (220) | 840 (344) | 0.20 |
| Sex (Female) | 37.5 (9/24) | 37.1 (23/62) | 0.97 |
| Antenatal Steroids | 91.7 (22/24) | 88.9 (56/63) | 1.00 |
| Suspected Chorioamnionitis | 50.0 (11/22) | 22.0 (13/59) | 0.01 |
| PROM | 29.2 (7/24) | 20.6 (13/63) | 0.40 |
| Oligohydramnios | 4.2 (1/24) | 14.3 (9/63) | 0.27 |
| Maternal diabetes | 4.2 (1/24) | 10.0 (6/60) | 0.67 |
| Maternal hypertension | 8.7 (2/23) | 31.2 (19/61) | 0.03 |
| Maternal GBS positive | 28.6 (2/7) | 29.4 (5/17) | 1.00 |
| Caesarean section | 41.7 (10/24) | 66.7 (42/63) | 0.03 |
| PPV (mask) | 91.7 (22/24) | 88.9 (56/63) | 1.00 |
| Apgar 1 min | 4 (4) | 5 (3) | 0.32 |
| Apgar 5 min | 7 (2) | 7 (3) | 0.07 |
| SNAP II Score | 14.0 (24.0) | 16.0 (16.0) | 0.94 |
| Number of Surfactant | |||
| 0 or 1 dose | 58.3 (14/24) | 73.0 (46/63) | 0.19 |
| >1 doses | 41.7 (10/24) | 27.0 (17/63) | |
| Postnatal steroids | 45.8 (11/24) | 39.7 (25/63) | 0.60 |
| Severe ROP† | 33.3 (8/24) | 22.6 (14/62) | 0.31 |
| NEC | 8.3 (2/24) | 6.4 (4/63) | 0.67 |
| Sepsis£ | 37.5 (9/24) | 31.8 (20/63) | 0.61 |
| Severe IVH§ | 25 (6/24) | 4.8 (3/63) | 0.01 |
BPD Bronchopulmonary dysplasia; GBS Group B streptococcus; IVH Intraventricular hemorrhage; NEC Necrotizing enterocolitis; PH Pulmonary hypertension; PPV Positive ventilation ventilation; PROM Prolonged rupture of membranes; ROP Retinopathy of prematurity; SNAP Score for neonatal acute physiology.
*All continuous variables expressed as medians (IQR) and categorical variables as % (n/N).
†Defined as stage 3 or greater, or treatment in either eye.
£Defined as presence of either positive blood or cerebral spinal fluid culture.
§Defined as the presence of periventricular or parenchymal hemorrhage on either side.