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. Author manuscript; available in PMC: 2020 Jul 3.
Published in final edited form as: Mod Pathol. 2020 Jan 3;33(6):1122–1134. doi: 10.1038/s41379-019-0445-z

Figure 2. Histopathology of Spitz melanomas with BRAF fusions.

Figure 2.

(A) and (B) Case 12-- NRF1-BRAF fusion. Sections show a highly cellular tumor with a thin overlying epidermis. The growth pattern is predominantly syncytial and the lesion is composed of epithelioid and spindled melanocytes with vesicular nuclei. (C) and (D) Case 4-- SOX6-BRAF fusion with amplification of the fusion gene. The melanocytes show vesicular nuclei and prominent nucleoli with heterogeneous pigment. There is mild epidermal hyperplasia.