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. Author manuscript; available in PMC: 2020 Aug 13.
Published in final edited form as: Lab Invest. 2020 Feb 13;100(6):837–848. doi: 10.1038/s41374-020-0405-8

Figure 2: Assessment of liver damage.

Figure 2:

H&E was performed along with serum levels of ALT and AST. By H&E we found typical PSC-like damage in Mdr2−/− mice compared to WT, which were unremarkable (A). DKO mice had ameliorated liver damage including less inflammation, fibrosis, lymphocytic infiltration and necrosis; however, chronic treatment with histamine to DKO mice restored these features recapitulating Mdr2−/− mice (A). Serum AST and ALT increased in Mdr2−/− mice that was reduced in DKO mice. Histamine treatment reversed amelioration in DKO mice and AST and ALT levels were similar to Mdr2−/− mice (B). Data are mean ± SEM of n = 12 experiments for IDEXX. *p<0.05 vs. WT; #p<0.05 vs. Mdr2−/− mice and &p<0.05 vs. DKO. Representative images x20.