Table 2.
Tumor regions studied for each of the 10 patients with ovarian immature teratomas including annotation of chromosomal gains/losses, fraction of genome with loss of heterozygosity, deduced meiosis failure mechanism of origin, and genes harboring somatic mutations.
| patient | clone | sample | tissue sequenced | tissue location | relationship with chemotherapy | chromosomal gains/losses | fraction of genome with LOH | centromeric LOH | telomeric LOH | deduced mechanism of origin | genes harboring somatic mutations |
|---|---|---|---|---|---|---|---|---|---|---|---|
| a | A | 3 | ovarian immature teratoma | L ovary | pre-treatment | none | 0.92 | - | - | III | PKFP |
| a | A | 1 | ovarian mature teratoma (neuroglial differentiation) | L ovary | pre-treatment | none | 0.92 | - | - | III | PKFP, CCS |
| a | A | 2 | ovarian mature teratoma (epidermal differentiation) | L ovary | pre-treatment | none | 0.93 | - | - | III | PKFP |
| a | A | 5 | disseminated immature teratoma | peritoneum | pre-treatment | none | 0.92 | - | - | III | PKFP, CIITA |
| a | A | 6 | disseminated yolk sac tumor | peritoneum | pre-treatment | none | 0.91 | - | - | III | PKFP, CIITA |
| a | A | 7 | disseminated mature teratoma (chondroid differentiation) | peritoneum | pre-treatment | none | 0.93 | - | - | III | PKFP |
| a | N/A | 4 | normal endometrium | uterus | pre-treatment | none | 0 | N/A | N/A | N/A | none |
| b | A | 10 | ovarian mature teratoma (epidermal differentiation) | R ovary | pre-treatment | none | 0.39 | - | +,− | II | none |
| b | B | 37 | ovarian immature teratoma | L ovary | pre-treatment | +3, +X | 0.33 | - | +,− | II | none |
| b | B | 36 | ovarian mature teratoma (neuroglial differentiation) | L ovary | pre-treatment | +3, +X | 0.32 | - | +,− | II | none |
| b | B | 38 | ovarian mature teratoma (epidermal differentiation) | L ovary | pre-treatment | +3, +X | 0.32 | - | +,− | II | none |
| b | B | 39 | disseminated immature teratoma | peritoneum | pre-treatment | +3, +X | 0.4 | - | +,− | II | none |
| b | B | 9 | disseminated immature teratoma | peritoneum | pre-treatment | +3, +X | 0.35 | - | +,− | II | VWA3B |
| b | B | 8 | disseminated mature teratoma (neuroglial differentiation) | peritoneum | pre-treatment | +3, +X | 0.34 | - | +,− | II | PLCB1 |
| b | B | 12 | disseminated mature teratoma (colonic differentiation) | peritoneum | post-therapy | +3, +X | 0.34 | - | +,− | II | VWA3B |
| b | B | 13 | gliomatosis peritonei | peritoneum | post-therapy | +3, +X | 0.4 | - | +,− | II | none |
| b | N/A | 11 | normal fallopian tube | R fallopian tube | pre-treatment | none | 0 | N/A | N/A | N/A | none |
| c | A | 16 | ovarian immature teratoma | R ovary | N/A | none | 0.38 | - | +,− | II | MRPL36 |
| c | A | 14 | ovarian mature teratoma (epidermal differentiation) | R ovary | N/A | none | 0.36 | - | +,− | II | none |
| c | A | 15 | ovarian mature teratoma (neuroglial differentiation) | R ovary | N/A | none | 0.39 | - | +,− | II | MRPL36 |
| c | N/A | 17 | normal fallopian tube | R fallopian tube | N/A | none | 0 | N/A | N/A | N/A | none |
| d | A | 19 | ovarian immature teratoma | L ovary | pre-treatment | +3 | 0.3 | + | +,− | I | SLC15A3, FOLH1 |
| d | A | 20 | ovarian mature teratoma (neuroglial differentiation) | L ovary | pre-treatment | +3 | 0.28 | + | +,− | I | none |
| d | A | 21 | ovarian mature teratoma (epidermal differentiation) | L ovary | pre-treatment | +3 | 0.28 | + | +,− | I | SLC15A3, NF1 |
| d | A | 22 | gliomatosis peritonei | peritoneum | pre-treatment | +3 | NA | + | +,− | I | none |
| d | A | 23 | disseminated primitive neuroectodermal tumor | peritoneum | post-therapy | +3 | 0.33 | + | +,− | I | several including TP53 |
| d | A | 24 | atypical gliomatosis peritonei | peritoneum | post-therapy | +3 | 0.27 | + | +,− | I | none |
| d | N/A | 18 | normal fallopian tube | L fallopian tube | pre-treatment | none | 0 | N/A | N/A | N/A | none |
| e | A | 28 | ovarian immature teratoma | R ovary | pre-treatment | none | 0.38 | - | +,− | II | none |
| e | A | 26 | ovarian mature teratoma (neuroglial differentiation) | R ovary | pre-treatment | none | 0.37 | - | +,− | II | none |
| e | A | 27 | ovarian mature teratoma (epidermal differentiation) | R ovary | pre-treatment | none | 0.37 | - | +,− | II | CHL1 |
| e | A | 29 | disseminated immature teratoma | peritoneum | pre-treatment | none | 0.39 | - | +,− | II | none |
| e | A | 30 | gliomatosis peritonei | peritoneum | pre-treatment | none | 0.49 | - | +,− | II | none |
| e | N/A | 25 | normal fallopian tube | R fallopian tube | pre-treatment | none | 0 | N/A | N/A | N/A | none |
| g | A | 40 | ovarian mature teratoma (epidermal differentiation) | R ovary | pre-treatment | none | 0.38 | - | +,− | II | none |
| g | B | 42 | ovarian immature teratoma | L ovary | pre-treatment | none | 0.31 | + | +,− | I | none |
| g | B | 44 | ovarian yolk sac tumor | L ovary | pre-treatment | none | 0.28 | + | +,− | I | none |
| g | C | 43 | ovarian mature teratoma (epidermal differentiation) | L ovary | pre-treatment | none | 0.29 | + | +,− | I | none |
| g | N/A | 41 | normal fallopian tube | L fallopian tube | pre-treatment | none | 0 | N/A | N/A | N/A | none |
| h | A | 47 | ovarian immature teratoma | R ovary | N/A | none | 0.23 | + | +,− | I | DCBLD1 |
| h | A | 45 | ovarian mature teratoma (epidermal differentiation) | R ovary | N/A | none | 0.23 | + | +,− | I | none |
| h | A | 46 | ovarian mature teratoma (neuroglial differentiation) | R ovary | N/A | none | 0.27 | + | +,− | I | none |
| h | A | 49 | gliomatosis peritonei | peritoneum | N/A | none | 0.25 | + | +,− | I | none |
| h | B | 52 | ovarian immature teratoma | L ovary | N/A | none | 0.94 | - | - | III | NOTCH2 |
| h | B | 50 | ovarian mature teratoma (neuroglial differentiation) | L ovary | N/A | none | 0.93 | - | - | III | none |
| h | B | 51 | ovarian mature teratoma (colonic differentiation) | L ovary | N/A | none | 0.94 | - | - | III | none |
| h | N/A | 48 | normal fallopian tube | L fallopian tube | N/A | none | 0 | N/A | N/A | N/A | none |
| i | A | 53 | ovarian immature teratoma | L ovary | pre-treatment | +14 | 0.33 | + | +,− | I | SEC23B |
| i | A | 54 | ovarian immature teratoma | L ovary | pre-treatment | +14 | 0.32 | + | +,− | I | none |
| i | A | 55 | ovarian mature teratoma (neuroglial differentiation) | L ovary | pre-treatment | +14 | 0.3 | + | +,− | I | SLC22A16 |
| i | A | 56 | ovarian mature teratoma (colonic differentiation) | L ovary | pre-treatment | +14 | 0.31 | + | +,− | I | none |
| i | N/A | 57 | normal fallopian tube | L fallopian tube | pre-treatment | none | 0 | N/A | N/A | N/A | none |
| j | A | 62 | ovarian mature teratoma (epidermal differentiation) | L ovary | N/A | none | 0.01 | - | - | III | none |
| j | B | 58 | ovarian immature teratoma | R ovary | N/A | none | 0.25 | +,− | +,− | IV | none |
| j | B | 59 | ovarian mature teratoma (neuroglial differentiation) | R ovary | N/A | none | 0.23 | +,− | +,− | IV | none |
| j | B | 60 | ovarian mature teratoma (colonic differentiation) | R ovary | N/A | none | 0.3 | +,− | +,− | IV | NT5C3A |
| j | B | 63 | gliomatosis peritonei | peritoneum | N/A | none | 0.57 | +,− | +,− | IV | none |
| j | N/A | 61 | normal fallopian tube | R fallopian tube | N/A | none | 0 | N/A | N/A | N/A | none |
| k | A | 64 | ovarian mature teratoma (neuroglial differentiation) | R ovary | post-therapy | +10 | 0.05 | - | +,− | II | none |
| k | A | 67 | disseminated immature teratoma | peritoneum | post-therapy | +10 | 0.3 | - | +,− | II | DTNB |
| k | A | 66 | disseminated mature teratoma (epidermal differentiation) | peritoneum | post-therapy | +10 | 0.34 | - | +,− | II | DTNB |
| k | N/A | 65 | normal fallopian tube | R fallopian tube | post-therapy | none | 0 | N/A | N/A | N/A | none |