Fig. 2.

GPR44 inhibition enhances glucose tolerance of human islets transplanted in diabetic mice. (a) Fasting blood glucose was measured on day 2, 10 and 17 in mice transplanted with human islets and treated with 6 or 60 mg/kg per day of AZ8154 or vehicle. (b, c) Blood glucose levels during IVGTT and the corresponding AUCs represent the difference in the level of glucose in mice transplanted with human islets and treated with AZ8154 or vehicle on day 10, 4 h after administration of AZ8154 (b) and on day 15, 18 h after administration of AZ8154 (c). Data are presented as means ± SD. The differences in AUC corresponding to the glucose levels during IVGTT were analysed with one-way ANOVA with Bonferroni corrections. **p < 0.01 and ***p < 0.001. For all analysis n = 8 mice/experimental group. D6, 6 mg/kg per day; D60, 60 mg/kg per day