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. 2020 Jun 10;40(6):BSR20200286. doi: 10.1042/BSR20200286

Table 3. Clusters of SMY–CHD PPI network.

Cluster Score Nodes Edges Targets and genes
1 48.148 55 1300 CCL2, TGFB1, VCAM1, FGF2, CXCL8, MMP1, IL2, APOE, EGFR, HMOX1, CRP, IFNG, MAPK1, NOS3, CASP3, ADIPOQ, PTGS2, ACE, SERPINE1, SELP, INS, IL6, AGTR1, EDN1, TLR4, VWF, SELE, TNF, ALB, CCL5, MAPK8, MPO, MMP3, TNFRSF1A, PLG, ELN, FN1, VEGFA, IL1B, AKT1, THBS1, PPARG, LEP, PECAM1, AGT, ICAM1, KDR, MMP9, TIMP1, IL10, IL18, ANXA5, MMP2, REN, CXCL12
2 14.489 46 326 CCR2, IGF1, PLAU, MET, FGF1, CTSB, IL1RN, CAT, SMAD3, PF4, KNG1, AR, HIF1A, IL1R1, PGF, GPT, HRAS, MAPK14, TNFRSF11B, GRB2, JAK2, SOD2, MAP2K1, MMP13, ADAM17, IL1A, MMP7, RHOA, NOS2, ESR1, ELANE, SRC, STAT1, HSP90AA1, CD40LG, CDC42, MDM2, BCL2L1, IGFBP3, CASP1, KIT, CDKN2A, AGER, FLT1, LGALS3, RETN
3 9.836 62 300 LCN2, TEK, HP, MTTP, ARG1, TF, FGB, XIAP, MAPK10, GGT1, APOA1, GCG, APOB, ABL1, PGR, APOA2, C3, TGFBR1, PIK3R1, CCR5, CX3CR1, HPGDS, SAA4, DPP4, GSK3B, PLAT, RBP4, PLA2G7, PTPN1, PARP1, TTR, RAF1, PTK2, IRS1, ANG, GC, HPRT1, F13A1, PLTP, PTPN11, JAK3, SOD1, ITGAL, F2, NQO1, F8, ALDOA, LCK, BMP2, THBD, MMP8, APOC1, SCARB1, CYP7A1, CFD, NOS1, F5, IL6R, CST3, NR3C1, PROC, IGF1R
4 9.719 65 311 APCS, AGTR2, SERPINC1, NAMPT, CTSG, NPC1L1, CDK2, NR1H4, LPL, LDLR, APOC3, ITGA2, VDR, RAC1, PON1, COG2, FGG, CSK, CETP, LPA, P2RY12, HMGCR, LIPC, LIPE, APOA5, CCNA2, BTK, INSR, LIPG, ACP5, CTSK, DNMT1, LCAT, CYBA, APOA4, HCK, ATIC, OLR1, FGA, PPBP, SOCS1, CLU, ADM, GSR, APOC2, ABCG5, NR1H3, ADORA1, GNB3, F2R, TGFB2, HSP90AB1, PSAP, MMP12, CYP19A1, ZAP70, SELPLG, SERPINA1, ABCG8, SYK, ITGB3, HSPD1, FABP4, ESR2, GHRL
5 5.333 7 16 RXRB, THRB, RARA, CDK7, CRABP2, RARG, RARB
6 4.526 20 43 GMPR2, ALAD, MTHFD1, ADK, PNP, MTR, BHMT, TK1, DTYMK, GPI, AHCY, PYGL, IMPDH2, PKLR, DHODH, SORD, UCK2, GBA, GLO1, HAGH
7 4.452 32 69 IMPDH1, LYZ, SORT1, PIK3CG, FABP5, AURKA, PRKCQ, RNASE3, CALM1, TFPI, ARSA, BACE1, AKR1B1, F10, RAC2, PPARA, GSTP1, PRKACA, ACE2, PROCR, LEPR, RHEB, MTHFR, PDPK1, GCK, CTSD, CPB2, F7, GM2A, RNASE2, HEXB, F11
8 4.25 9 17 CYP2C9, AKR1C3, CYP3A4, SULT1E1, HSD17B1, NR1I3, CYP11B2, STS, HSD11B1
9 4 4 6 CDA, CTSS, CHIT1, LTA4H
10 4 5 8 GSTA3, SULT1A1, ADH1C, GSTM1, ADH1B
11 4 5 8 PDE4B, DCK, PDE4D, TYMS, NT5M
12 4 4 6 RAB11A, EEA1, RAB5A, DNM2
13 4 4 6 UAP1, GALE, GNPDA1, GNPDA2
14 3.5 17 28 PIK3C2A, GSTM2, PCK1, GLRX, ITK, CYP2C8, BCHE, GSTA1, CYP2C19, G6PD, RXRA, GSTO1, FGF21, INPP5D, SULT2A1, WAS, ANGPTL4
15 3.333 4 5 APRT, GMPR, PDE5A, UMPS
16 3 3 3 ITGA2B, PAPSS1, BRAF
17 3 7 9 DHFR, TPH1, MAOB, GART, HNMT, SHMT1, MAOA
18 3 3 3 LDHB, NME2, AK1
19 2.571 8 9 CLPP, ACADM, GATM, HADH, PDHB, OTC, ME2, ARG2