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. 2020 Jun 10;40(6):BSR20200286. doi: 10.1042/BSR20200286

Table 4. Clusters of SMY known–CHD PPI network.

Cluster Score Nodes Edges Targets and genes
1 47.66 54 1263 TLR4, VWF, SELE, AKT1, TNF, ALB, JUN, CASP3, MAPK8, MPO, MMP3, PLG, FN1, ELN, VEGFA, IL1B, THBS1, PPARG, LEP, PECAM1, AGT, ICAM1, KDR, ESR1, TIMP1, MMP9, IL10, IL18, MMP2, CXCL12, CCL2, IGF1, TGFB1, CAT, VCAM1, FGF2, CXCL8, MMP1, IL2, APOE, HMOX1, CRP, IFNG, NOS3, ADIPOQ, PTGS2, ACE, IL1A, SERPINE1, SELP, INS, IL6, AGTR1, EDN1
2 10 46 225 CDKN2A, PLA2G7, CHRM2, LCAT, NR3C1, PROC, HP, IRS1, MTTP, AGTR2, SERPINC1, PPBP, SOCS1, AHR, AR, SLC2A4, PGR, ABCG5, PCSK9, ADORA1, F13A1, APOA1, GCG, APOB, GNB3, ADRA2A, DPP4, MIF, SOD1, ABCG8, CETP, C3, P2RY12, MMP8, CHRM4, THBD, OPRD1, CCR5, CX3CR1, APOC1, CYP7A1, APOA5, SCARB1, OPRM1, SAA4, PLAT
3 9.571 43 201 ACP5, F5, FGF21, CYBA, CST3, GHRL, APOA4, OLR1, NAMPT, FGA, TF, FGB, NPC1L1, APOC2, CHRM3, CHRM1, LPL, KALRN, PLTP, APOC3, F2R, CALCA, PON1, ABCA1, COG2, ITGA2B, ADRA1A, APOA2, CYP19A1, F8, CHRM5, LPA, LEPR, HMGCR, LIPC, LIPE, HTR2A, ADRA1B, ADRA1D, ITGB3, F7, NOS1, LIPG
4 5.917 25 71 NOS2, FLT1, HSP90AA1, RETN, RELA, CCR2, LCN2, STAT1, IL1RN, SMAD3, PF4, KNG1, HIF1A, TNFRSF1A, IL1R1, GPT, TNFRSF11B, GGT1, LDLR, PLAU, SOD2, F2, ELANE, CD40LG, IGFBP3
5 4.5 5 9 MAOB, SLC6A2, HTR3A, SLC6A3, DRD1
6 3.714 8 13 PLA2G2A, GABRA2, ADH1C, ALDH2, CYP2C8, ADH1B, NR1I3, CYP2C19
7 3.667 7 11 CYP3A4, GSTM1, CYP1A2, NR1I2, SLC6A4, MAOA, CYP2J2
8 3.333 4 5 CALM2, SCN5A, CALM3, PPP3CA
9 3.2 6 8 NCOA2, USF1, ANGPTL4, RXRA, SMARCA4, CD36
10 3 3 3 ADRB2, NPY, ACHE
11 3 3 3 CPB2, F10, TFPI
12 3 3 3 CACNA1S, KCNMA1, KCNH2