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. 2020 Jun 10;3:298. doi: 10.1038/s42003-020-1030-1

Fig. 6. A schematic model for the conformational transition of AdhE and its implication for AdhE activity.

Fig. 6

Conformational transition of AdhE from compact (left) to extended (right) spirosomes. The NAD+ binding pockets are highlighted in yellow. ALDH and ADH domains are shown in light gray and royal blue, respectively. Cofactor binding at the inter-helical interface in the compact spirosome might induce the formation of extended spirosomes. The substrate channels between the ALDH and ADH catalytic sites are indicated with red dotted arrows.