Table 1.

MSI to quantify pairwise interactions. The table presents pairwise MSI for examples from the literature. The higher the value of MSI, the better is the benefit the organism derives through this interaction. The references in Column 1 and 2 pertain to the source of the respective GSMMs. The value in bold in each row indicates the MSI of the organism that benefits from the interaction.

Organism A	Organism B	MSI(A)	MSI(B)	Comments
Ketogulonicigenium vulgare[25]	Bacillus megaterium[25]	0.107	0.0	B. megaterium acts as a helper strain for K. vulgare by providing additional metabolites [36], [37]
Clostridium cellulolyticum[28]	Clostridium acetobutylicum[26]	0.039	0.001	C. acetobutylicum helps C. cellulolyticum to grow and metabolize cellulose under non-favourable conditions through metabolic exchanges [38]
Pichia stipitis[29]	Saccharomyces cerevisiae[27]	0.063	0.025	P. stipitis benefits from the interaction with S. cerevisiae by taking up additional metabolites from the latter (this study)
Yarrowia lipolytica[30]	Cellulomonas fimi[30]	0.119	0.014	C. fimi provides additional metabolites to Y. lipolytica in a co-culture setup [17]
Desulfovibrio vulgaris[30]	Methanococcus maripaludis[30]	0.176	0.03	D. vulgaris benefits from the interaction with M. maripaludis[39]