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. 2020 May 27;23(6):101201. doi: 10.1016/j.isci.2020.101201

Figure 5.

Figure 5

Dysregulation of EMT Network in Molecular Subtypes of Conventional UC and SCC

(A) Expression patterns of representative genes of the EMT regulatory network in molecular subtypes of conventional UC and SCC.

(B) EMT scores in molecular subtypes of conventional UC and SCC.

(C) Gene Set Enrichment Analysis (GSEA) analysis of TP53 (left) and TP63 (right) target genes in SCC compared with conventional UC.

(D) Boxplot analysis of expression levels of CDH1, TJP1, and CLDN1 in molecular subtypes of conventional UC and SCC.

(E) Boxplot analysis of expression levels of SNAI2, SNAI3, TWIST1, ZEB1, and ZEB2 in molecular subtypes of conventional UC and SCC.

(F) Boxplot analysis of EMT scores in molecular subtypes of conventional UC and SCC.

(G) GSEA analysis of 175 EMT target genes in SCC compared with conventional UC. In panels C, D, E, F, and G, a p value < 0.05 was considered statistically significant.