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. 2020 May 27;23(6):101201. doi: 10.1016/j.isci.2020.101201

Figure 6.

Figure 6

Expression Pattern of Immune Cell Infiltrate and Immune Checkpoint Genes in Molecular Subtypes of Conventional UC and SCC

(A) Expression pattern of immune cell infiltrate. Top to bottom: B cell, T cell, CD8, MacTH1, and dendritic cell expression clusters.

(B) Boxplot of immune scores calculated using the gene expression profile shown in (A) for molecular subtypes of conventional UC and SCC.

(C) Heatmap of CIBERSORT scores for 22 immune cell types in molecular subtypes of conventional UC and SCC. A p value < 0.05 was considered statistically significant.

(D) Proportion of cases with significant CIBERSORT scores in conventional UC and SCC (left). Proportion of cases with significant CIBERSORT scores in molecular subtypes of conventional UC and SCC (right).

(E) Expression of immune checkpoint genes in conventional UC and SCC in relation to their molecular subtypes.

(F) Boxplot of ADORA2A mRNA expression levels in molecular subtypes of conventional UC and SCC. In panels B, D, and F, a p value < 0.05 was considered statistically significant.