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. 2020 May 27;23(6):101201. doi: 10.1016/j.isci.2020.101201

Figure 7.

Figure 7

Immunohistochemical Validation Studies of Molecular Features of SCC when Compared with Conventional UC

(A) The immunohistochemical expression signatures of luminal, basal, and neuroendocrine markers in representative luminal and basal cases of conventional UC and SCC on a tissue microarray (TMA) composed of conventional UC (n = 76) and SCC (n = 14). Scale bars, 40 μm.

(B) The immunohistochemical expression of CD3 and CD8 T cells in representative luminal, basal, and double-negative cases of conventional UC and SCC on a TMA composed of conventional UC (n = 76) and SCC (n = 14). Scale bars, 40 μm.

(C) Western blot documenting the overexpression of synaptophysin, MSI1, E2F1, and ADORA2A with loss of E-cadherin in fresh frozen tissue of conventional UC and SCC. All cases of conventional UC are of the basal subtype.