Expression levels of CYB5R3 measured by Western blots in protein extracts obtained from liver (a) and hind limb skeletal muscle (b) of wild-type and Tg mice. Depicted data are mean ± SEM of 4 replicates. In all graphs, asterisks without a letter refer to statistically significant differences between genotypes, whereas “AL” followed by asterisks indicates statistically significant differences between ad libitum and CR for a given genotype. Significant interactions between diet and genotype are also indicated when appropriated. In Figs. 2, 3, 4, 5, 6, and 7, representative Western blots and Ponceau S-stained lanes as loading control are included below each graph. a.u. arbitrary units