Table 3.
Metabolic pathways associated with age and weight for Birmingham only (left) and all locations (right). Pathways in italics are associated with either age or weight in both analyses
| Birmingham | All locations | ||||||
|---|---|---|---|---|---|---|---|
| Column | Factor | Metabolic pathway | p value | Column | Factor | Metabolic pathway | p value |
| Positive | Weight | Tryptophan metabolism | 0.0002 | Positive | Weight | Tryptophan metabolism | 0.0000 |
| Linoleate metabolism | 0.0003 | Urea cycle/amino group metabolism | 0.0000 | ||||
| Urea cycle/amino group metabolism | 0.0003 | Xenobiotics metabolism | 0.0001 | ||||
| Arginine and Proline Metabolism | 0.0005 | Arginine and proline metabolism | 0.0001 | ||||
| Xenobiotics metabolism | 0.0008 | Glycine, serine, alanine and threonine metabolism | 0.0003 | ||||
| Glycerophospholipid metabolism | 0.0013 | Drug metabolism - cytochrome P450 | 0.0006 | ||||
| Vitamin B3 (nicotinate and nicotinamide) metabolism | 0.0041 | Prostaglandin formation from arachidonate | 0.0007 | ||||
| Tyrosine metabolism | 0.0068 | Aspartate and asparagine metabolism | 0.0025 | ||||
| De novo fatty acid biosynthesis | 0.0073 | Androgen and estrogen biosynthesis and metabolism | 0.0325 | ||||
| Glycosphingolipid metabolism | 0.0092 | Negative | Weight | Dynorphin metabolism | 0.0008 | ||
| Pentose and Glucuronate Interconversions | 0.0175 | Vitamin A (retinol) metabolism | 0.0064 | ||||
| Alanine and Aspartate Metabolism | 0.0364 | De novo fatty acid biosynthesis | 0.0075 | ||||
| Prostaglandin formation from arachidonate | 0.0427 | Vitamin E metabolism | 0.0193 | ||||
| Purine metabolism | 0.0427 | Glycerophospholipid metabolism | 0.0491 | ||||
| Negative | Weight | Phytanic acid peroxisomal oxidation | 0.0043 | Positive | Age | Vitamin B6 (pyridoxine) metabolism | 0.0029 |
| Vitamin A (retinol) metabolism | 0.0043 | Mono-unsaturated fatty acid beta-oxidation | 0.0066 | ||||
| Urea cycle/amino group metabolism | 0.0091 | Di-unsaturated fatty acid beta-oxidation | 0.0066 | ||||
| Linoleate metabolism | 0.0184 | Omega-6 fatty acid metabolism | 0.0143 | ||||
| Fatty acid activation | 0.0204 | Tyrosine metabolism | 0.0273 | ||||
| De novo fatty acid biosynthesis | 0.0271 | Biopterin metabolism | 0.0361 | ||||
| Positive | Age | Saturated fatty acids beta-oxidation | 0.0015 | Urea cycle/amino group metabolism | 0.0400 | ||
| Di-unsaturated fatty acid beta-oxidation | 0.0015 | Alanine and aspartate metabolism | 0.0486 | ||||
| Mono-unsaturated fatty acid beta-oxidation | 0.0019 | Negative | Age | Alanine and aspartate metabolism | 0.0002 | ||
| Purine metabolism | 0.0021 | Arginine and proline metabolism | 0.0002 | ||||
| Porphyrin metabolism | 0.0022 | Urea cycle/amino group metabolism | 0.0002 | ||||
| Fatty acid metabolism | 0.0022 | TCA cycle | 0.0002 | ||||
| Prostaglandin formation from dihomo gama-linoleic acid | 0.0032 | Glutamate metabolism | 0.0002 | ||||
| Alanine and aspartate metabolism | 0.0033 | Beta-alanine metabolism | 0.0002 | ||||
| Omega-6 fatty acid metabolism | 0.0034 | Purine metabolism | 0.0002 | ||||
| Dimethyl-branched-chain fatty acid mitochondrial beta-oxidation | 0.0046 | Butanoate metabolism | 0.0002 | ||||
| Phytanic acid peroxisomal oxidation | 0.0058 | Pyrimidine metabolism | 0.0003 | ||||
| De novo fatty acid biosynthesis | 0.0105 | Glycolysis and gluconeogenesis | 0.0003 | ||||
| Nitrogen metabolism | 0.0121 | Carbon fixation | 0.0003 | ||||
| Omega-3 fatty acid metabolism | 0.0233 | Histidine metabolism | 0.0004 | ||||
| N-Glycan degradation | 0.0259 | Glycine, serine, alanine and threonine metabolism | 0.0004 | ||||
| Heparan sulfate degradation | 0.0259 | Aspartate and asparagine metabolism | 0.0005 | ||||
| Chondroitin sulfate degradation | 0.0259 | Lysine metabolism | 0.0006 | ||||
| Lysine metabolism | 0.0369 | Valine, leucine and isoleucine degradation | 0.0006 | ||||
| Drug metabolism - other enzymes | 0.0369 | Fatty acid oxidation, peroxisome | 0.0007 | ||||
| Carbon fixation | 0.0479 | Tyrosine metabolism | 0.0007 | ||||
| Negative | Age | Arginine and proline metabolism | 0.0061 | C5-Branched dibasic acid metabolism | 0.0014 | ||
| Pyrimidine metabolism | 0.0063 | Methionine and cysteine metabolism | 0.0022 | ||||
| Purine metabolism | 0.0064 | Phytanic acid peroxisomal oxidation | 0.0025 | ||||
| Alanine and aspartate metabolism | 0.0064 | Nitrogen metabolism | 0.0025 | ||||
| TCA cycle | 0.0066 | Vitamin B1 (thiamin) metabolism | 0.0025 | ||||
| Glycine, serine, alanine, and threonine metabolism | 0.0067 | Propanoate metabolism | 0.0049 | ||||
| Beta-Alanine metabolism | 0.0077 | Pyruvate metabolism | 0.0049 | ||||
| Histidine metabolism | 0.0082 | Vitamin B6 (pyridoxine) metabolism | 0.0066 | ||||
| Ascorbate (vitamin C) and aldarate metabolism | 0.0097 | Glutathione metabolism | 0.0101 | ||||
| Phytanic acid peroxisomal oxidation | 0.0108 | Glyoxylate and dicarboxylate metabolism | 0.0209 | ||||
| Urea cycle/amino group metabolism | 0.0147 | Aminosugars metabolism | 0.0287 | ||||
| Glycosphingolipid metabolism | 0.0168 | Glycerophospholipid metabolism | 0.0313 | ||||
| Butanoate metabolism | 0.0168 | Phosphatidylinositol phosphate metabolism | 0.0491 | ||||
| Phosphatidylinositol phosphate metabolism | 0.0225 | ||||||
| Glyoxylate and dicarboxylate metabolism | 0.0250 | ||||||
| C5-Branched dibasic acid metabolism | 0.0267 | ||||||
| Aspartate and asparagine metabolism | 0.0290 | ||||||
| Glutamate metabolism | 0.0316 | ||||||
| Caffeine metabolism | 0.0399 | ||||||
| N-Glycan degradation | 0.0413 | ||||||
| Heparan sulfate degradation | 0.0413 | ||||||
| Chondroitin sulfate degradation | 0.0413 | ||||||