TABLE 1.

Demographic and clinical data of HSP patients and healthy control group.

	HSP patients	Healthy controls
	N = 31	N = 36
Gender	16 F, 15 M	26 F, 10 M
Disease onset (years)	27 ± 17
Age at first MRI (years)	43.5 ± 12	43.65 ± 10
Age at follow-up MRI (years)	44 ± 12.8	47.8 ± 7.4
Disease duration at first MRI (years)	14 ± 13
Disease duration at follow up MRI (years)	18 ± 13
SPastic Gate gene
SPG4	40% (12)
SPG5	13% (4)
SPG30	10% (3)
SPG3	10% (3)
SPG8	6% (2)
SPG11	6% (2)
SPG7	3% (1)
SPG72	3% (1)
SPG10	3% (1)
SPG31	3% (1)
SPG not defined	3% (1)