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. 2020 Jun 4;11:1006. doi: 10.3389/fimmu.2020.01006

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Copyright © 2020 Fattizzo, Giannotta, Zaninoni, Kulasekararaj, Cro and Barcellini.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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cytokine levels in PNH positive and PNH negative AIHA patients, in age and sex matched controls (N = 40), and in a cohort of classic hemolytic PNH cases (N = 28). IFN-γ and IL-17 levels were lower in PNH positive versus PNH negative AIHA (p = 0.07 for both). No significant p values were obtained. TNF-α and TGF-β levels are not shown into the figure; their values were (mean ± SD): TNF-α 0.2 ± 0.2 pg/mL in PNH+AIHA, 0.2 ± 0.1 pg/mL in PNH-AIHA, 0.23 ± 0.29 pg/mL in classic PNH, and 1.3 ± 0.9 pg/mL in healthy controls. TGF-β 3,249 ± 1,570 pg/mL in PNH+AIHA, 3,295 ± 1,697 pg/mL in PNH-AIHA, 21,010 ± 602 pg/mL in classic PNH, and 3,160 ± 1,884 pg/mL in healthy controls. *represent outlier values.