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. 2020 Jun 4;11:1105. doi: 10.3389/fimmu.2020.01105

Figure 2.

Figure 2

Diagram of IL-10 and histone modification. Histone acetylation induces the production of analgesic factors such as IL-10. EIS protein can significantly increase the level of acetylation of histone H3 (Ac-H3), thereby increasing the expression of IL-10. Histone acetylase inhibitors and 5-aza treatment increased IL-10 mRNA expression. Inhibition of histone deacetylase by histone deacetylase inhibitors, histone acetylation induces spinal cord production of analgesic factors including IL-10. Conversely, the inhibition of anacardic acid down-regulated KAT2B, thereby reducing the occupancy of KAT2B and H4K5ac by the IL-10 promoter, resulting in down-regulation of IL-10 expression by transcriptional silencing. Similarly, imipramine upregulates histone deacetylase 11, which inhibits the acetylation of the IL-10 promoter resulting in a decrease in IL-10 production. KAT2B, lysine acetyltransferase 2B; H4K5ac, histone H4 lysine 5 acetylation; HDAC, histone deacetylase; Ac-H3, acetylation level of histone H3; EIS, enhanced intracellular survival.