Table 2.
Research on miRNA and IL-10 in diseases.
| MiRNA | Disease | Samples (n) | miRNA detection method | IL-10 detection method | miRNA expression | IL-10 level | References |
|---|---|---|---|---|---|---|---|
| MiRNA-141 | Breast cancer | Breast cancer (56), Healthy volunteer (6) | RT-qPCR | ELISA | DOWN | DOWN | (45) |
| MiRNA-146a/150 | Elderly hip fracture | Elderly male Sprague Dawley rats (40), Young male SD rat (40) | RT-qPCR | ELISA | UP/DOWN | UP | (46) |
| MiRNA-10a | CAD | CAD (69), Control group (69) | Real-time PCR | ELISA | DOWN | DOWN | (47) |
| MiRNA-155 | Lyme carditis | Mir155−/− mice (3), IL-10−/− Mir155−/− (DKO) mice (3) | RT-qPCR | ELISA | UP | DOWN | (51) |
| MiRNA-19a | Allergen-related inflammation | Male C57BL/6 mice, miRNA-17-92fl/fl mice | RT-qPCR | ELISA | UP | DOWN | (54) |
| MiRNA-210 | Preeclampsia | Late-onset preeclampsia (29), Normal uncomplicated pregnancies (27), Healthy and non-pregnant women (10) | RT-qPCR | ELISA | UP | DOWN | (55) |
| MiRNA−21-5p | HSP | HSP group (16), NHSP group (10) | Real-time PCR | FCM | DOWN | DOWN | (56) |
| rno-miRNA−211 | ARDS | 5-week-old male Wistar rats (12), Controls (12) | Microarray and Taqman assay | ELISA | UP | DOWN | (57) |
| MiRNA-223 | RA | RA patients (22), Control group (19) | RT-qPCR | ELISA | UP | DOWN | (58) |
| rno- miRNA−30b-5p | Uveitis | Female Lewis rats (160) | Real-time PCR | ELISA | DOWN | UP | (59) |
| MiRNA-410 | SLE | SLE patients (20), Healthy controls (20) | RT-qPCR | ELISA | DOWN | UP | (60) |
| MiRNA−98 | HCC | Paired HCC (25), Adjacent normal tissues (25) | RT-qPCR | ELISA | DOWN | UP | (61) |
| MiRNA−98 | Lung cancer | Male patients (5), Female patients (5) | RT-qPCR | ELISA | UP | DOWN | (62) |
| MiRNA-98 | Myocarditis | Myocarditis heart tissue (3), Normal heart tissue (3) | RT-qPCR | ELISA | UP | DOWN | (63) |
| MiRNA-98 | Allergic diseases | Asthma (10), Allergic rhinitis (14) | Real-time PCR | FCM | UP | DOWN | (64) |
| MiRNA-98 | Atherosclerosis | Atherosclerosis (20), Healthy participants (20) | RT-qPCR | RT-qPCR | UP | DOWN | (9) |
RT-qPCR, reverse transcription-quantitative polymerase chain reaction; CAD, coronary artery disease; HSP, Henoch-Schonlein purpura; ARDS, acute respiratory distress syndrome; RA, rheumatoid arthritis; SLE, systemic lupus erythematosus; HCC, hepatocellular carcinoma; FCM, flow cytometry.