Table 1.
Proteins associated with the 14 ORFs of SARS-CoV.
| UniprotKB Entry | Protein | Gene | Function |
|---|---|---|---|
| P0DTC1 | Replicase polyprotein 1a (R1a) | ORF1a | Viral transcription/replication |
| P0DTD1 | Replicase polyprotein 1ab (R1ab) | ORF1b | Viral transcription/replication, ribosomal frame shift |
| P0DTC2 | Spike glycoprotein (S) | S | Attachment and host cell entry |
| P0DTC3 | Protein 3a | ORF3a | Forms potassium-ion channel on the host cell membrane, and aids in virion assembly |
| P0DTC4 | Envelope small membrane protein (E) | E | Virion assembly and morphogenesis |
| P0DTC5 | Membrane protein (M) | M | Virion assembly and morphogenesis |
| P0DTC6 | Non-structural protein 6 | ORF6 | Interferon antagonist |
| P0DTC7 | Protein 7a (NS7A) | ORF7a | Activates the release of pro- inflammatory cytokines for viral pathogenesis |
| P0DTD8 | Protein 7b (NS7B) | ORF7b | Structural and accessory protein |
| P0DTC8 | ORF8 (different) | Unknown, but interacts with protein E | |
| P0DTC9 | Nucleoprotein (N) | N | Viral genome packaging, transcription, and virion assembly |
| P0DTD3 | Uncharacterized protein 14 | ORF9b | Unknown |
| P0DTD2 | Protein 9b | ORF10 | Unknown |
| A0A66DJA2 | Hypothetical ORF10 protein | ORF14 | Expression not known |