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. 2020 Jun 4;8:363. doi: 10.3389/fcell.2020.00363

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Copyright © 2020 d’Aldebert, Quaranta, Sébert, Bonnet, Kirzin, Portier, Duffas, Chabot, Lluel, Allart, Ferrand, Alric, Racaud-Sultan, Mas, Deraison and Vergnolle.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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mRNA expression of proliferation markers [Cyclin D1 and Ki67 (A) and (B) respectively], immaturity markers [LGR5 and Ephrin B2 (C) and (D) respectively], and differentiation markers [Carbonic Anhydrase-1: CA1, Cytokeratine-20: KRT20 (E), Carbonic Anhydrase-1: CA1 (F), and Mucin 2: MUC2 (G)] in 10 days cultured organoids from controls (circles), control organoids exposed to inflammatory cocktail (IL-1β, TNF-α, and IL-6, at 10 ng/ml) from day 3 to day 10 of cultures (squares) and organoids from IBD patients (triangles): ulcerative colitis (UC) patients (opened triangles) and Crohn’s disease (CD) patients (closed triangles). Data were normalized to GAPDH. Red lines in graphs represented medians. No statistical significant difference was observed.