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. 2020 Jun 10;10:9389. doi: 10.1038/s41598-020-66329-7

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© The Author(s) 2020

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Correlation of gene mutation frequencies with TIME subtypes revealing EP300 mutation as significantly associated with an immune-activated TIME: Significant association of gene mutation frequencies with specific TIME subtypes for 9 genes of all HNSCC (A), 11 genes of HPV-negative HNSCC (B) and 8 genes of HPV-positive HNSCC. Mutations in TP53 and EP300 are found in all three groups.