Figure - PMC

Skip to main content

An official website of the United States government

Here's how you know

Here's how you know

Official websites use .gov
A .gov website belongs to an official government organization in the United States.

Secure .gov websites use HTTPS
A lock ( ) or https:// means you've safely connected to the .gov website. Share sensitive information only on official, secure websites.

View full-text article in PMC

. 2020 Jun 10;10:9389. doi: 10.1038/s41598-020-66329-7

Search in PMC
Search in PubMed
View in NLM Catalog
Add to search

© The Author(s) 2020

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

PMC Copyright notice

PanCancer correlation of EP300 mutation and expression status with anti-tumor immunity. (A) Display of EP300 mutation frequency for 18 common solid malignancies (n = 7564) and association with cytolytic activity in comparison to EP300 wt tumors. HNSCCs, esophageal SCC, stomach carcinomas and prostate carcinomas have a significantly higher cytolytic activity in EP300 mut tumors. (B) PanCancer correlation of EP300 expression status with anti-tumor immunity for 18 solid malignancies showing a significantly higher cytolytic activity in in EP300 low tumors. (C) PanCancer distribution of EP300 mutations with most mutations at the lysine acetyltransferase domaine KAT. (D) Percentage of EP300 mutations with increased cytolytic activity relative to all mutations with spiking mutation counts at TAZ1 and IBID. Mut: mutated; wt: wildtype; CytAct: cytolytic activity; ADCA: adenocarcinoma; Ca: carcinoma; SCC: squamous cell carcinoma; HCC: hepatocellular carcinoma; RCC: renal clear cell carcioma; cholang: cholangiocellular; TAZ: Transcriptional adapter zinc finger; KIX: kinase inducible domain of CREB interacting domain; BR: Bromodomain; PHD: Plant homeodomain; IBID: Interferon binding domaine.