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. 2020 Jun 10;10:9389. doi: 10.1038/s41598-020-66329-7

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© The Author(s) 2020

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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PanCancer analyses of metabolic phenotypes in relationship to EP300 expression: (A) Absolute upregulation frequency of 24 genes involved in glycolysis and 31 genes invovled in OXPHOS with significant upregulation of all OXPHOS genes, except for ATP12A in EP300 low tumors and significant downregulation of 14 glycolysis genes in EP300 low tumors. (B) PanCancer expression of metabolic genes (red: 24 genes involved in glycolysis; blue: 31 genes involved in OXPHOS) with predominance of glycolytic genes in EP300 high tumors and predominace of OXPHOS-associated genes in EP300 low tumors. Font size is relative to upregulation frequency. (C) Relative upregulation frequency of glycoyltic and OXPHOS-associated genes with a dominantly glycolysis-dependent metabolism in EP300 high tumors and an OXPHOS-dependent metabolism in EP300 low tumors. ** p < 0.01, ***p < 0.0001.