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. 2020 Jun 10;10:9378. doi: 10.1038/s41598-020-66296-z

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© The Author(s) 2020

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Protein network by MetaCore built with the differential proteins found (blue spheres) adding FGFR1, VEGFR-1, PDGF receptor, known to be targets of the Nintedanib treatment. PDGF-R-beta, FGFR1, VEGFR-1, HP, PDGF receptor result central hubs. Green edges indicate «induction», red edges are correlated with inhibition, while grey edges indicate an unspecified effect. Bold light blue line represent well-known canonical pathways.