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. 2020 Jun 10;10:9400. doi: 10.1038/s41598-020-66417-8

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© The Author(s) 2020

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Pamoic acid (PA) activates Akt and p38 MAPK signaling in the ischemic brain. (A) PA treatment increased the concentration of pAkt at 24 hours after the MCAO, One-Way ANOVA, F_(2/18) = 9.515, **P = 0.0039 (Bonferroni multiple comparison tests), values are min to max. n = 7. (B) PA treatment increases the pGSK-3β at 24 h after the MCAO, one-Way ANOVA, F_(2/11) = 4.652, *p = 0.0332 (Bonferroni multiple comparison test) values are min to max, (n for Sham = 4, n for MCAO = 4, n for MCAO + PA = 6), (C) PA treatment increased the p38 MAPK at 24 h after the MCAO, One-Way ANOVA, F_(2/19) = 9.089, *P = 0.0221 (Bonferroni multiple comparison test), values are min to max, (n for Sham = 4, n for MCAO = 4, n for MCAO + PA = 6). (D) PA treatment increased the activity of p38 MAPK 48 h after the MCAO, One-Way ANOVA, F_(2/9) = 7.598, *P = 0.0290 (Bonferroni multiple comparison tests), values are min to max, n = 4. (E,F) The effect of PA was lost when combining with Triciribine, One-Way ANOVA, F_(2/17) = 19.21, **P = 0.0029, ***P = 0.0001 (Bonferroni multiple comparison tests), values are means ± s.e.m, (n for MCAO = 7, n for MCAO + PA = 8, MCAO + PA + Triciribine =5).