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. 2020 Jun 10;10:9426. doi: 10.1038/s41598-020-66442-7

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© The Author(s) 2020

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Comparative analysis of immunoglobulin (Ig) heavy chains (Ig α, Ig μ, and Ig heavy chain V-1, V-II, and V-III) in tears isolated from non-KC control individuals and KC patients. The error bars depict the standard deviation. All patient samples were included in the analysis. Statistical analysis determined based on a two-way ANOVA with Sidak’s multiple comparisons test and α set to 0.05. (d and e) Refer to Table 1 for the description of the regions included in the different species.