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. 2020 Jun 10;10:9420. doi: 10.1038/s41598-020-66113-7

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© The Author(s) 2020

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Repetitive blast exposure increases BBB permeability to radiolabeled albumin. A significant increase (**p ≤ 0.01) in brain/serum (uμl/g) ratios of ^99mTc-albumin was observed in whole brain at 72 h after repetitive mTBI (3X blast; n = 12) compared to 1X blast (n = 12), and sham control mice (n = 12). One-way ANOVA post-hoc Newman-Keuls. Values represent means ± SEM and are expressed as microliters per gram of brain tissue. Brain/serum ratios were calculated by dividing the cpm per brain by the cpm per microliter in the corresponding serum and then by the weight of the brain.