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. 2020 Jun 10;10:9420. doi: 10.1038/s41598-020-66113-7

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© The Author(s) 2020

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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L-NAME improves sensorimotor impairment in mice exposed to repetitive blast. 3X blast and sham mice received L-NAME mice. In shams, L-NAME treatment had no significant effect on performance and were thus pooled (sham-vehicle n = 10, and sham L-NAME-treated n = 11). There was a significant overall difference (p ≤ 0.045) between shams, blast vehicle-treated (n = 14), and blast L-NAME-treated (n = 14) mice. Mice exposed to repetitive mTBI one month prior exhibited impaired sensorimotor performance on a rotarod task (p ≤ 0.05) compared to sham controls (pooled mice, mice administered L-NAME). Post-hoc analysis revealed blast L-NAME-treated mice performed significantly better than blast vehicle-treated mice (p ≤ 0.02). Two-way ANOVA Helmert’s test. Values represent means ± SEM.