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. 2020 Jun 4;11:1213. doi: 10.3389/fmicb.2020.01213

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Copyright © 2020 Liu, Wang, Lin, Das, Wang, Qi, Yang, Xue, Mao and Luo.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Heatmap of antibiotic resistance genes (ARGs) in the three parts of colon within three groups and the network analysis revealing the co-occurrence patterns between abundance of microbial taxa and that of ARG subtypes. Heatmap colors reflect relative abundance from low (blue) to high (red). The nodes in network were colored according to ARG types and microbial genera that increased (red) or decreased (green) after AMX exposure, and the edges were colored according to positive (red) or negative (blue) correlation. A connection represents strong and significant (P value < 0.05, R > 0.6) correlation. The size of each node is proportional to the number of connections, that is, degree.