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. 2020 Jun 4;7:218. doi: 10.3389/fmed.2020.00218

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Copyright © 2020 Truffault, Bourhis, Chaput, Calais, Robin, Le Pennec, Lucia, Leclère, Gujral, Vera, Salaün, Schick and Abgral.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Example of 65 year-old woman, with T3N1M0 oropharyngeal squamous cell carcinoma. Before the emergence of reflex otalgia and neck pain, a PET-CT was performed 2 months after radiotherapy and showed a local persistant disease. PET_A (images on the top) and PET_R (images on the bottom) were not scanned in treatment position (NTP) and coregistered with RR method (on the left) and ER method (on the right). A₄₀ subvolume (yellow line), R₄₀ subvolume (blue line) and A₄₀∩R₄₀ (red area). The OF (A₄₀, R₄₀) index was calculated respectively at 0 and 0.80 for RR and ER registration methods.