Table 2.
Plasma toxicokinetic parameters of NBBS following a single gavage administration in male and female rats.a
| Parameterb | Dose (mg/kg) | ||
|---|---|---|---|
| Male | 20 | 60 | 200 |
| Cmax (ng/mL) | 316 ± 46 | 1,200 ± 290 | 3,440 ± 500 |
| Cmax /D (ng/mL)/(mg/kg) | 15.8 | 20.0 | 17.2 |
| Tmax (h) | 0.355 ± 0.105 | 0.378 ± 0.266 | 0.228 ± 0.183 |
| K01 half-Life (h) | 0.0809 ± 0.0353 | 0.0696 ± 0.0668 | 0.0361 ± 0.0373 |
| K10 half-Life (h) | 1.42 ± 0.17 | 2.72 ± 0.58 | 2.70 ± 0.21 |
| Cl1_F (mL/h/kg) | 26,000 ± 3,600 | 11,500 ± 2,400 | 14,100 ± 1,800 |
| V1_F (mL/kg) | 53,300 ± 9,900 | 45,400 ± 12,900 | 54,900 ± 8,800 |
| AUC (h*ng/mL) | 771 ± 107 | 5,190 ± 1100 | 14,200 ± 1,800 |
| AUC/D (h*ng/mL)/(mg/kg) | 38.6 | 86.5 | 71.0 |
| Female | |||
| Cmax (ng/mL) | 1,540 ± 250 | 3,890 ± 450 | 15,200 ± 1900 |
| Cmax /D (ng/mL)/(mg/kg) | 77.0 | 64.8 | 76.0 |
| Tmax (h) | 0.539 ± 0.134 | 0.392 ± 0.116 | 0.237 ± 0.175 |
| K01 half-Life (h) | 0.158 ± 0.065 | 0.0824 ± 0.0346 | 0.0353 ± 0.0330 |
| K10 half-Life (h) | 1.24 ± 0.16 | 1.93 ± 0.16 | 3.55 ± 0.28 |
| Cl1_F (mL/h/kg) | 5,370 ± 880 | 4,810 ± 500 | 2,460 ± 270 |
| V1_F (mL/kg) | 9,640 ± 2,250 | 13,400 ± 1,900 | 12,600 ± 1,800 |
| AUC (h*ng/mL) | 3,730 ± 610 | 12,500 ± 1,300 | 81,400 ± 9,100 |
| AUC/D (h*ng/mL)/(mg/kg) | 187 | 208 | 407 |
a
Based on one-compartment model with first order input, first order output and 1/Y∧2 weighting.
b
Values given are mean ± standard error for up to 3 animals.