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Brain:plasma ratios of NBBS following gavage administration of NBBS in rats and mice based on the systemic exposure parameters.
| Dose (mg/kg) |
Male rat |
Female rat |
Male mouse |
Female mouse |
||||
|---|---|---|---|---|---|---|---|---|
| Cmax | AUC | Cmax | AUC | Cmax | AUC | Cmax | AUC | |
| 20 | 5.3 | 1.8 | 3.1 | 2.0 | 1.7 | 0.7 | 0.7 | 0.4 |
| 60 | 3.8 | 1.4 | 3.0 | 2.6 | 1.5 | 0.9 | 1.0 | 0.9 |
| 200 | 3.9 | 2.5 | 1.7 | 2.3 | 1.5 | 1.4 | 1.4 | 1.5 |
