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Bleomycin-induced senescence was dependent on the PI3K/Akt/mTOR signaling pathway. (a) The PI3K/Akt/mTOR signaling pathway was activated in bleomycin-treated cells, as determined by western blotting. (b) Akt and mTOR phosphorylation were significantly increased in lung cancer cells following transfection with PTEN siRNA. Values given as mean ± SD. *P < 0.05, **P < 0.01, ***P < 0.005 (n = 3).
