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(a) The minimum percentage change to control individual INaCa, ICaL and RyR to trigger SDs. (b–f) Time-course of the membrane potential, Irel, [Ca2+]i, [Ca2+]up, and [Ca2+]rel, for control and for 89% INaCa, 113% ICaL, and 138% RyR after the last stimulated AP (black triangle). SERCA, sarcoplasmic reticulum Ca2+-ATPase; SD, spontaneous depolarization; RyR, ryanodine receptors. (Online version in colour.)
