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(a) Bifurcation diagram of ICaL and INaCa at 100% SERCA. Shaded region illustrates the parameter range where SDs occur. (b–f) Time-course of the membrane potential, Irel, [Ca2+]i, [Ca2+]up, and [Ca2+]rel for control and at 140% ICaL and 125% INaCa for 100%, 54%, and 107% SERCA after the last stimulated AP (black triangle). SERCA, sarcoplasmic reticulum Ca2+-ATPase; SD, spontaneous depolarization; AP, action potential. (Online version in colour.)
