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Bifurcation analysis for SERCA-RyR (a) and SERCA-ICal (b), respectively. (c) Bifurcation analysis for SERCA-INaCa. Shaded region illustrates the parameter range where SDs occur. The cross marks roughly where the shift in the Ca2+ handling took place. SERCA, sarcoplasmic reticulum Ca2+-ATPase; SD, spontaneous depolarization; RyR, ryanodine receptors. (Online version in colour.)
