Figure 6.

A schematic overview of the two hypotheses we explore. Hypothesis 1 assumes the collected data represent a perfect, idealized voltage-clamp experiment where any experimental artefacts have been perfectly compensated by the amplifier and leak subtraction, so all the observed variability is rooted in biological variability (varying conductance and model kinetics in every cell), we term these ‘independent kinetics models’. Hypothesis 2 assumes that the observed variability is due to differences in the voltage-clamp experimental artefacts, and that all of the cells share identical ion channel kinetics (although the maximum conductance is allowed to vary across cells), we term these ‘identical kinetics models’. (Online version in colour.)