Table 2.
Combined cecum and colon scores (median [range]) for enterocolitis and GALT hyperplasia
| Enterocolitis | GALT hyperplasia | |||||
| Inflammation (scale, 0–4) | Edema (scale, 0–4) | Epithelial defects (scale, 0–4) | Total score (scale, 0–12) | GALT score (scale, 0–8) | n | |
| GF control | ||||||
| 3 mpi | 0.25 (0–1.5) | 0 (0–0.5) | 0.25 (0–1.5) | 0.75 (0–3.5) | 1 (0.5–1) | 8 |
| 6 mpi | 0.5 (0–1.5) | 0.25 (0–2) | 0.5 (0–1.5) | 1 (0–4.5) | 1.5 (0–2) | 8 |
| 7–9 mpi | 1.25 (0–2) | 0 (0–1) | 1 (1–2) | 2.75 (1–4) | 2.25 (1.5–3) | 6 |
| 11–14 mpi | 1 (0–1) | 0.5 (0–0.5) | 1.5 (1–2) | 3 (1–3) | 2 (1.5–3) | 7 |
| Hb-mono | ||||||
| 3 mpi | 1.5 (0–2.0)b | 0.5 (0–1.5)b | 1 (0–1.5) | 2.75 (1.5–5)b | 3.5 (1–4.5)b | 8 |
| 6 mpi | 1.75 (1–2.5)b | 1 (0–1.5) | 0 (0.75–1.5) | 3.5 (1.5–5)a | 4 (3–5)b | 8 |
| 7–9 mpi | 1.5 (1–2.5) | 0.5 (0–1.5) | 1 (0.5–2) | 3 (2–5.5) | 4.5 (3.5–6)c | 13 |
| 11–14 mpi | 1.75 (0.5–2.5)a | 0.25 (0–1.5) | 1 (0.5–3)* | 2.75 (1–8) | 4.5 (2–5.5)b | 12 |
a
P < 0.05,
b
P < 0.01,
c
P < 0.001 regarding comparison of controls with Hb-mono mice at respective time points.