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. 2020 Jun 11;10(6):622–628. doi: 10.1016/j.jceh.2020.06.002

Table 2.

Studies Reporting a Liver Injury in Patients With Coronavirus Infection 19 (COVID 19).

Author, year Total number of patients Proportion with preexisting liver disease Manifestations
Guan W, 202011 1099 23 (2.3%) Elevation of
AST 168/757 (22.2%)
ALT 158/741 (21.3%)
TB 76/722 (10.5%)
Cai Q, 202031 298 8 (2.7%) 44 (14.8%)
More in patients with severe disease (36.2%) than those with mild disease (9.6%)
Fan Z, 202032 148 NA 75 (50.7%)
Wang D, 202033 138 4 (2.9%) Mild AST elevation, particularly in patients with severe disease
Chen N, 20208 99 NA Abnormality in
ALT 28 (28%)
AST 35 (35%)
TB 18 (18%)
Low albumin 97 (98%)
Shi H, 202034 81 7 (9%) 43 (53%)
Xu X, 202035 62 7 (11%) 10 (16.1%)
Yang X, 202036 52 NA 15 (29%)
Huang C, 20207 41 1 (2%) 15 (31%)
Zhang B, 202037 82 2 (2.4%) 64 (78%)
Huang Y, 202037 36 NA Elevation of
ALT 4/30 (13.33%)
AST 18/31 (58.06%)
TB 4/31 (12.90%)
Cholankeril G, 202017 116 Abnormal LFT 26/65 (40%)
Wu J, 202038 80 NA 3 (3.75%)

AST, aspartate aminotransferase; ALT, alanine aminotransferase; TB, total bilirubin; LFT, liver function test; NA, not available.