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. 2020 Jun 4;11:793. doi: 10.3389/fphar.2020.00793

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Copyright © 2020 Lara, Adinolfi, Harwood, Philpott, Barden, Di Virgilio and McNulty

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Activation of P2X7 receptor. Structures show the top (A) and side view (B) of the P2X7 trimer in the Apo-closed state (PDB file: 6U9V) and ATP bound open state (PDB file: 6U9W). Each monomer is represented in a different color (blue, red or yellow). ATP binding to the trimer leads to a rotation of each monomer around its respective turret leading to the opening of a side fenestration and an ion channel through the plasma membrane (PM). Renderings were generated from the rat P2X7 structure (McCarthy et al., 2019) using PyMOL (https://pymol.org/).