TABLE 2.
AUCs for biomarkers obtained post-Cis-Carb and -Ifos infusion to discriminate for presence of AKI
| Cis-Carb group | Ifos group | |||
|---|---|---|---|---|
| Biomarker | AUC (SE) for AKI | AUC (SE) for AKI, adjusted for age | AUC [SE] for AKI | AUC (SE) for AKI, adjusted for age* |
| NGAL (ng/mg creatinine) | ||||
| Day 1 (postinfusion) | 0.40 (0.15) | 0.64 (0.15) | 0.80 (0.13) | 0.82 (0.12) |
| Day 2 (morning post) | 0.38 (0.13) | 0.63 (0.14) | 0.60 (0.15) | 0.72 (0.13) |
| IL-18 (pg/mg creatinine) | ||||
| Day 1 (postinfusion) | 0.41 (0.17) | 0.57 (0.16) | 0.73 (0.16) | 0.74 (0.15) |
| Day 2 (morning post) | 0.47 (0.15) | 0.68 (0.17) | 0.68 (0.13) | 0.69 (0.13) |
*
Adjustment for age was performed using logistic regression whereby the outcome was AKI and both the biomarker and age were included in the logistic regression analysis, with postregression calculation of AUC.