Official websites use .gov
A
.gov website belongs to an official
government organization in the United States.
Secure .gov websites use HTTPS
A lock (
) or https:// means you've safely
connected to the .gov website. Share sensitive
information only on official, secure websites.
Synthesis of apalutamide via late-stage, thiophosgene-free cyclization. Reaction conditions: (a) 12, CDI, DBU, i-Pr2NEt, THF, 60 °C; (b) HCl, 2-PrOH, 70 °C; (c) 28, DMA, KOAc, CuBr, TMEDA, 120 °C; (d) 1,1′-thiocarbonylbis(pyridine2(1H)-one, DMAP, DMA, 90 °C.
