Scheme 10.
Synthesis of enzalutamide via functionalization of thiohydantoin. Reaction conditions: (a) thiourea, Et3N, DMF, 80–90 °C; (b) 4-bromo-3-(trifluoromethyl)-benzonitrile (55), NaH, DMF, rt; (c) 28, NaH, DMF.
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